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This property increases myocardial oxygen delivery in patients with coronary artery spasm, and is responsible for the effectiveness of isoptin in vasospastic prinzmetal s or variant as well as unstable angina at rest.

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Asystole occurred after second/third degree AV block and was usually short in durationwith spontaneous cardiac action returning within seconds in the form of a sinus rhythmRef]

TheophyllineVerapamil therapy may inhibit the clearance and increase the plasma levels of theophylline.

NitratesVerapamil has been given concomitantly with shortand long-acting nitrates without any undesirable drug interactionsThe pharmacologic profile of both drugs and the clinical experience suggest beneficial interactions.

Other medications can affect the removal of verapamil from your bodywhich may affect how verapamil worksExamples include erythromycinrifamycinssuch as rifampinritonavirStJohn’s wortamong others.

Gynecomastia occurred in older male patients on prolonged treatmentand was reversible upon discontinuation of this drugRef]

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caution must be used with phenotyping since some co-administered drugs can influence measurement of tpmt activity in order verapamil isoptin , and recent blood transfusions will misrepresent a patients actual tpmt activity.

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